A new University of Michigan study explores why people with Alzheimer’s disease often lose their sense of direction, focusing on the role of the retrosplenial cortex, a brain region tied to spatial orientation. Researchers have discovered a unique type of neuron in this area that may hold important clues about how the brain tracks our spatial location. This discovery could bring scientists closer to understanding and eventually addressing why disorientation is such a common and troubling symptom of Alzheimer’s disease.