As the opioid epidemic continues to devastate communities, fentanyl remains one of the most lethal substances, with just two milligrams enough to cause an overdose. But researchers at the University of Michigan are exploring an intriguing possibility—could certain fentanyl analogs hold the key to reversing its deadly effects? In this article, Dr. Jess Anand, a researcher in the Department of Pharmacology at the University of Michigan, discusses groundbreaking efforts to uncover potential solutions within the chemistry of these powerful drugs.