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Study: Most ‘Silent’ Genetic Mutations Are Harmful, Not Neutral, a Finding With Broad Implications

June 8, 2022

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5-15 mins
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Saccharomyces Cerevisiae Yeast
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Presented by Michigan News

Jianzhi Zhang, U-M Department of Ecology and Evolutionary Biology Marshall W. Nirenberg Collegiate Professor and study senior author, discusses research regarding genetic mutations. Zhang notes that the strong nonneautrality of synonymous mutations would have implications for studying human disease mechanisms and other aspects as synonymous mutations, previously believed to be benign, are harmful. The faculty expert further calls for efforts in predicting and identifying pathogenic synonymous mutations, highlighting findings from the research study.

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