RNA Modification ‘Pivotal’ for Protein Linked to Neurodegeneration in ALS

February 24, 2023


Read time:

5-15 mins
Presented by Health Lab

Michigan Medicine researchers are focusing on an RNA modification known as m6A. TDP-43, which helps regulate the processing of RNA, may be responsible for the death of nerve cells in ALS and frontotemporal dementia. Sami Barmada, M.D., Ph.D., senior author, and Angela Dobson Welch and Lyndon Welch, Research Professor of Neurology at the University of Michigan Medical School, discuss RNA methylation and the loss of brain cells in patients.

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