Antiphospholipid syndrome is an understudied autoimmune disease that is nevertheless a leading cause of deadly blood clots and late-term pregnancy loss. Recent studies suggest that APS patients can produce a flurry of overactive immune cells, called neutrophils, that release toxic webs of proteins and DNA called neutrophil extracellular traps, or NETs. Ray Zuo, M.D., discusses the discovery of a new class of functional autoantibodies.
