Scleroderma is an autoimmune disease that causes a buildup of scar tissue on organs. A study conducted suggests that scleroderma patients have reduced expression of the A20 molecule, which normally prevents the formation of fibrosis. But this altered A20 expression or function in scleroderma contributes to fibrosis. John Varga, MD., professor of rheumatology, discusses the importance of the A20 molecule and how it has not been linked to scleroderma until now.
